For the European group, the betatrophin levels increased in the GDM patients (SMD = 1.53; 95% CI: 1.29–1.78, P < 0.010); however, for the Asian group, the difference was not significant (SMD = -0.61; 95% CI: -3.87–2.65, P = 0.710). This evidence concerns the gene ANGPTL8 and gestational diabetes.