For women with BMI ≥ 28 kg/m2, the circulating betatrophin levels increased in the GDM women (SMD = 1.53; 95% CI: 1.3–1.75, P < 0.001); however, for women with BMI < 28 kg/m2, the difference was not significant (SMD = 0.22; 95% CI: -1.56 to 2, P = 0.810). This evidence concerns the gene ANGPTL8 and gestational diabetes.