In addition, some higher values of expression of Bax and Bad and a lower expression of Bcl-2 were particularly evident into the necrotic lesions; this might account for the increased Bax and Bad expression registered in malignancies and might confirm that the two major mechanisms of cell death, apoptosis and necrosis, are simultaneously activated within the tumor damaged area [40,41]. The gene discussed is BAD; the disease is neoplasm.