Besides, lower serum leptin level may benefit not only in preventing insulin resistance and lipotoxicity, but also in restraining the progression of NASH by preventing fibrogenesis, since there are recent evidences that leptin acts as a profibrogenic cyokine in sinusoidal microenvironment by activating hepatic stellate cells to produce transforming growth factor β1 and other pro-inflammatory cytokines [1, 45, 48, 49]. This evidence concerns the gene LEP and metabolic dysfunction-associated steatohepatitis.