Using the same approach outlined above, we found that shRNA knockdown of MYOD resulted in efficient knockdown prior to tumor cell implantation (Figure 5F,K) and reduced xenograft growth of both RD and RMS559 cells when assessed by total body luciferase imaging completed overtime (p<0.01; Figure 5F–H,K–M and Figure 5—figure supplement 1B,C). Here, MYOD1 is linked to neoplasm.