Taken together, the results in Figs 4 and 5 clearly demonstrate the importance of the BMI1/let‐7i/ERK3 pathway in regulating head and neck cancer cell migration: Both BMI1 and ERK3 promote migration and let‐7i, as an intermediator for BMI1 and ERK3, inhibits cell migration. Here, MAPK6 is linked to head and neck cancer.