CRB3 and cancer: YAP overexpression leads to the loss of contact inhibition and YAP deregulation has been identified in various types of cancer.8 As shown in recent studies, YAP may be a therapeutic target for cancer.8, 55 CRB3 is a tumour suppressor and is expressed at low levels in cancer tissues.21, 56 Furthermore, CRB3 inhibited the function of YAP in vitro.