Hematopoietic factors such as GRB2, Rac1 and CEBPA, and apoptotic factors such as FOXO1, PDCD4 and BCL2, respectively, have been shown to be regulated by miRNA182.51, 52, 53 Given the unresolved regulation of Hes1 in myeloid differentiation and leukemias,54, 55 we provided evidence for a post-transcriptional regulatory mechanism in Notch signalling pathway mediated by miRNA182. The gene discussed is HES1; the disease is leukemia.