TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive: Previously, a TGF-β/FOXO signalling was suggested to be contributing to TKI resistance and EMT transition seen in CML stem cells.40, 45, 46 Wnt signalling that has been implicated in CML stem cells also shown to be upstream regulator of expression of miRNA182.47, 48 Given the diversity of regulatory signalling pathways upstream and downstream to miRNA182, different stages of CML might require rewiring of the miRNA182-dependent transcriptional programs.