Therefore, we looked at brain swelling and aquaporin 4, the well-known glial water channel whose expression is increased after stroke and is extensively described for its contribution to brain edema formation and development.15 We did not observe any modification of the percentage of swelling between WT and ColXV KO mice treated or not with rtPA 2 days after stroke (Figure 3a: P=0.2444). Here, AQP4 is linked to Stroke.