First, we did not observe any changes in astrogliosis or microgliosis between WT and ColXV KO mice treated or not with rtPA 3 days after stroke, measured respectively as GFAP (Figures 5a and b: P=0.8330) or Iba1 (Figures 5c and d: P=0.6932) reactivity in the peri-ischemic area. This evidence concerns the gene GFAP and stroke disorder.