In this regard, VEGF-A is of particular interest for its involvement in mechanisms mediating neuroprotection, angiogenesis, neurogenesis, neuronal migration and survival and axon guidance.16, 17 Nevertheless, previous studies caution the use of VEGF for stroke therapy at appropriate dose and time post-stroke.35 Here, we have focused on short-term time points: MRI was conducted at 2 days post injury, and the mice were sacrificed one day later. This evidence concerns the gene VEGFA and Stroke.