This hypothesis is comforted by previous reports showing the ability of rtPA to cleave/degrade CSPGs.31, 32 Proteolytic cleavages of ColIV, ColXV and ColXVIII produce fragments with anti-angiogenic activities: arrestin, canstatin or tumstatin for ColIV, restin for ColXV and endostatin for ColXVIII.33, 34 Increasing post-stroke repair constitutes one direction of interest to establish new effective therapies. The gene discussed is COL4A3; the disease is Stroke.