SYNCRIP and colorectal cancer: In colorectal cancer, the region of chromosome 6q14, where HNRNPQ (symbol: SYNCRIP) is located, has no alternation or deletion, indicating that the increased hnRNP Q may not result from gene amplification.27, 28 It is possible that the increased hnRNP Q mRNA in tumors might be due to mechanisms involving transcriptional upregulation or post-transcriptional regulation, such as miRNA.29 The content of cancer cells might contribute additional signals in the posttranslational modification of hnRNP Q1 for its retention in the cytoplasm and its function in the translational regulation of mRNAs.26