YAP1 and polycystic ovary syndrome: The effect of locus determined by GWAS lasts a lifetime, but the epigenetic changes are dynamic during growth process.[21,22] Studies have suggested that DNA methylation regulation exists in ovarian follicle growth and atresia.[23] YAP1, known as a pivotal transcriptional co-activator of Hippo pathway, participates in many signaling pathways that regulate organic morphology, including ovary enlargement that is one of the major manifestations of PCOS.[24,25] YAP1 could combine with a series of transcription factors and act as a modulator through phosphorylation.