YAP1 and polycystic ovary syndrome: GWAS has showed that the single nucleotide polymorphisms of YAP1 are significantly different between PCOS and controls and it appears to be a new susceptibility gene for PCOS.[7,15] Our study aims to detect the methylation status of YAP1 promoter in ovary GCs of PCOS patients and explores the epigenetic factors that motivate the pathogenesis.