A different maternal and fetal concentration of soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelial growth factor has been described in presence of hypertensive disorders, leading to endothelial dysfunction, hypertension, and proteinuria in animal models.[35,36] According to these results, fetal aIMT could be the vascular sign of biochemical imbalance and placental insufficiency, and might be considered in more studies on late HDP prediction with ultrasound examination parameters. The gene discussed is FLT1; the disease is placental insufficiency.