CCL2 and alkaline phosphatase measurement: While in 5 ug/kg group mice, apart from the slight elevation in monocyte chemotactic protein-1 (MCP-1) levels in pancreatic tissue (Fig. 5C), we failed to observe the typical pathological changes of AP and there was no significant difference in pathological scores between the 5 ug/kg group mice and the normal mice (Fig. 5A,B).