SOCS1 and melanoma: Downregulation of SOCS1 in B16F10-Nex2 murine melanoma cells decreased the expression of several growth factor receptors e.g., insulin receptor α-chain, EGFR (phosphorylated), and FGFR-4 and -5 and a possible attenuation of MAPK signaling pathways would be compatible with alterations in the cell cycle S phase, decreased proliferation, and decreased resistance to anoikis, present in these cells16.