Subcutaneous injection of B16shR-SOCS1 cells in CD4 T-cell KO and WT mice promoted otherwise, a significant reduction of lung metastatic nodules (Fig. 6C), suggesting that SOCS1-silencing elicits a protective immune response against metastatic melanoma mediated by CD8+ T-cells. This evidence concerns the gene SOCS1 and metastatic melanoma.