LGALS3 and heart disorder: Likewise, in multivariate analyses, we observed that previous cardiac disease, NYHA scale and high Gal-3 [OR (95%CI): 4.37 (1.16–16.41), p = 0.029; 2.93 (1.26–6.85), p = 0.013 and 3.29 (1.07–10.11), p = 0.037, respectively] remained independent predictors of fibrosis (Table 3).