For all of patients harbouring EGFR-activating mutations, the median OS was 17.5 months (95% CI 15.055 to 19.945), and a Cox analysis showed that adenocarcinoma (Hazard Ratio 5.650, 95% CI 2.223 to 14.362, p < 0.001), recurrent disease (Hazard Ratio 1.976, 95% CI 1.291 to 3.025, p = 0.002), or treatment with EGFR-TKIs (Hazard Ratio 2.525, 95% CI 1.748 to 3.646, p < 0.001) were associated with improved OS. The gene discussed is EGFR; the disease is adenocarcinoma.