Although a number of clinical factors (old age, hypertension, anticoagulants, hyperglycemia), radiological findings (large infarct, proximal occlusion, leukoaraiosis) and several blood biomarkers (MMP-9, c-FN, PAI-1, TAFI and S100B) have been identified and linked to an increased risk of ICH24, 25, 26, to date no reliable biomarkers are able to accurately predict the risk of ICH before tPA administration. This evidence concerns the gene SERPINE1 and Abnormal cerebral white matter morphology.