The results of Western-blot demonstrated that the expression of fibrosis-associated genes, including Col1a2, Col3a1, α-SMA and CTGF, were significantly suppressed by miR-26b in moue CFs, however, circRNA_000203 could dramatically promote the expressions of the above genes, and eliminated the antifibrotic effect of miR-26b (Fig. 4D). The gene discussed is ACTA1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.