When the ratio of quantified glycoproteins of HBV-related HCC patients to healthy controls was defined as >1.2 or <0.8, eight of them, such as Gal-3BP, α-2-macroglobulin and α-1-antitrypsin, were up-regulated, and the other nine, such as Complement factor B and Vitamin D-binding protein, were down-regulated. This evidence concerns the gene CFB and hepatocellular carcinoma.