For example, protein levels of CCNB1 (cyclin B1) were significantly higher (P = 7.28E‐13) in breast tumors with alterations in FAM83 family genes, whereas protein levels of GATA3 (P = 3.79E‐07), PGR (P = 5.77E‐07), and ESR1 (P = 9.20E‐07) were significantly lower (Fig. 5C). The gene discussed is ESR1; the disease is breast neoplasm.