To search for the mechanisms for FAM83 family members contributing to tumor development, we investigated whether mutations in any genes were enriched in tumors with alterations of FAM83 family members and found that tumors with alterations in FAM83 family members were significantly more likely to also have a TP53 mutation (P = 2.04E‐14), whereas they were significantly less likely to have mutations in PIK3CA (P = 8.73E‐6) and CDH1 (E‐cadherin) (P = 2.13E‐05) (Fig. 5B; Table S3). This evidence concerns the gene CDH1 and neoplasm.