CYP1B1 and Hypertension: In male rodents, Cyp1b1 has been shown to mediate DOX-induced cardiotoxicity via the metabolism of arachidonic acid to the cardiotoxic mid-chain hydroxyeicosatetraenoic acid metabolites [48], and hypertension-associated cardiomyopathy via the metabolism of testosterone to the more cardiotoxic metabolite, 6β-hydroxytestosterone [52].