This conclusion is also consistent with our recent finding that Plac1, which is overexpressed in MMTV-PPARδ mice, mediates immune tolerance in murine breast cancer cells by upregulating the expression of chemokines necessary for MDSC-mediated activation of Tregs (H. Yuan and R. I. Glazer, unpublished results). This evidence concerns the gene PLAC1 and breast carcinoma.