The respective Yin/Yang functions of PPARδ and PPARγ are consistent with the ability of PPARδ to enhance survival through the PI3K and PDK1 pathways in response to wound healing [26, 27], as well as with the proliferative and angiogenic response of breast cancer and endothelial cells to conditional activation of PPARδ [28]. Here, PPARD is linked to breast carcinoma.