In addition to activation of the prostaglandin axis, PPARδ increases expression of the acute phase proteins Saa1, Saa2, S100a8, and S100a9, as well as several members of the kallikrein gene family [31], all of which are elevated in ER+ breast cancer [59, 60] and whose promoter regions contain PPREs. The gene discussed is PPARD; the disease is breast carcinoma.