Very recently, five IgG proteins including Ig gamma-2B chain C region (IGH-3), Ig lambda-2 chain C region (IGLC2), IGKC and Ig kappa chain V-V region HP R16.7 were identified as carbonylated proteins in the serum of 3-month-old triple transgenic AD mice (3× Tg-AD mice) [43]. The gene discussed is IGLC2; the disease is Alzheimer disease.