Similar to CEP112 variants, PHACTR1 regulates cardiac α-actin isoform ratio [44] and actomyosin assembly [45]; CNTN5 is associated with neuron function [46]; PTPRT regulates synaptic function and neuronal development [33] and serves as a genuine susceptibility locus for rheumatoid arthritis[33]; FHOD3, is a key regulator in the cardiac muscle [47] and sarcomere organization in striated muscle cells [48]; and PRIM2 is involved in DNA replication and transcription and is crucial for normal growth and development [49]. The gene discussed is PRIM2; the disease is rheumatoid arthritis.