To identify whether BDKRB2 is involved in NMI-induced activation of MAP kinase signaling pathway, we assessed MAPK/ERK signaling pathway in NMI-upregulation HCC cells transfected with siBDKRB2 or scrambled siRNA and found that the reduced level of BDKRB2 led to the inactivation of ERK pathway (Supplementary Figure 8). Here, BDKRB2 is linked to hepatocellular carcinoma.