Thus, we found that BDKRB2 expression levels in the metastatic HCC cell lines were much higher than that in the non-metastatic ones (Figure 5A), and detected that the BDKRB2 transcript expression level was significantly down-regulated after NMI knockdown in HCC-LM3 by qRT-PCR (Supplementary Figure 4). The gene discussed is BDKRB2; the disease is hepatocellular carcinoma.