After NMI knockdown, the expression levels of MAPK signaling pathway members, including Raf1, MAPK11, MAP3K14 and MAP3K2, which are associated with cancer invasion and metastasis [20–22], were obviously decreased HCC-LM3 (Supplementary Table 3, Supplementary Figure 3). This evidence concerns the gene MAPK11 and hepatocellular carcinoma.