MET and cervical cancer: As a result, HPV-16 E6 may act through miR-23b and then c-MET to regulate apoptosis in human cervical cancer cells as: (i) silencing of c-MET was shown to induce apoptosis in SiHa cells (Figure 8A); (ii) miR-23b, the negative regulator of c-MET, also triggered apoptotic induction (Figure 8A); (iii) the anti-miR-23b inhibitor reduced the apoptosis induced by knockdown of either c-MET or HPV-16 E6 (Figure 8B).