To determine if Survivin contributes functionally to the maintenance of EBV genomes in BL cells, we assayed the effect of Survivin shRNA depletion in two different BL cells, MUTU I and Raji, which have very high levels of EBV episomes compared to NPC cell line C666-1 (Figure 8H). The gene discussed is BIRC5; the disease is nasopharyngeal carcinoma.