MAPK3 and Familial prostate cancer: Although the functional implication of this regulation in prostate cancer progression is still unclear, PKD1 is an important prosurvival signaling protein in normal and cancer cells that functions by regulating multiple signaling pathways, such as stimulating NF-κB, ERK1/2, and Akt and inhibiting JNK and p38 [20, 25, 40].