KDR and hepatocellular carcinoma: Selective inhibition of the VEGF pathway has been at the focus of intense research in the area of molecularly targeted therapy of HCC, particularly after sorafenib, a dual Raf/Map kinase inhibitor with concurrent inhibitory power on VEGF-R2, 3 and platelet-derived growth factor receptor, has become the standard of care in the treatment of advanced HCC [1, 66].