Of note, there are nine genes among these targets that when mutated are known causes for inherited peripheral neuropathies (IPN) and hereditary spastic paraplegia (HSP) (Inf2, Sox10, Wnk1, Med25, Fa2h, Bscl2, Slc12a6, Kif1a and Kif5a) [13, 21, 29, 31, 40–42, 52]. The gene discussed is INF2; the disease is hereditary spastic paraplegia.