HSPB1 and neuroblastoma: Notably, the formation of large protein aggregates, typically seen for C-terminal mutations in HSPB1 [1, 9], could not be detected in fibroblasts originating from the patient (HSPB1-P182L) or control individual, nor in the neuroblastoma cell lines stably expressing levels of the HSPB1 constructs that were comparable with the endogenous protein.