HSPB1 and distal hereditary motor neuropathy: So far, 26 mutations (including 22 missense mutations) have been found in HSPB1 that are responsible for axonal Charcot-Marie-Tooth neuropathy (CMT2F), distal hereditary motor neuropathy (dHMN) and amyothropic lateral sclerosis (ALS) [7, 11, 14, 27, 49].