In the logistic regression analyses adjusted by age, we found that that compared with the healthy controls, the HBV patients had significantly higher serum levels of PLA2G2A (P < 0.05), Furthermore, among the various groups of patients, the serum levels of PLA2G2A consistently increased with the progression of HBV diseases which is in the order of HCC > LC > CHB patients (Fig. 1). Here, PLA2G2A is linked to hepatocellular carcinoma.