Tau pathology (Fig. 1, Additional file 1: Figure S1, Additional file 2: Figure S2, Additional file 3: Figure S3) in the form of tangles, skein-like inclusions, and punctate staining was observed to a greater extent in ALSci than ALS, especially in the ACC and superior frontal cortex. Here, MAPT is linked to amyotrophic lateral sclerosis.