DACT2 and esophageal squamous cell carcinoma: The CGI shore region in DACT1 is more likely to be methylated but is not cancer-specific and isn’t related to the transcriptional inhibition of DACT1. The simultaneous methylation of DACT1 and DACT2 may play important roles in progression of ESCC, and may serve as prognostic biomarkers for ESCC patients.