According to the definitions used, 9% had an amplified tumor (TOP1/CEN-20 ratio ≥ 2 and TOP1/CEN-2 ratio ≥ 2), 44% had a tumor harboring a q-20 polysomy (TOP1/CEN-20 ratio ≤ 2 and TOP1/CEN-2 ratio ≥ 2), and 46% had a tumor that was neither amplified nor a polysomy. This evidence concerns the gene TOP1 and neoplasm.