Having demonstrated the potent inhibitory effect of SFN/mR-214 on c-MYC and giving the fact that c-MYC plays critical roles in chemotherapy resistance in various tumor types [28, 32] and depletion of c-MYC with antisense RNA or RNAi restored sensitivities in tumor cells [33, 34], we reasoned that SFN could increase cell sensitivity to chemotherapeutic drug-mediated cytotoxicity. Here, MYC is linked to neoplasm.