For example, known disease genes BRCA2, CDH1, IDH1, CDKN2A, NME1 and FGFR3 frequently occurred at the top one in seven cancer types (including BC, GC, GBM, MB, MM, NB and OC), even though only two or three known-disease genes existed in NB, GBM and MB gene lists. The gene discussed is CDH1; the disease is cancer.