For example, known disease genes BRCA2, CDH1, IDH1, CDKN2A, NME1 and FGFR3 frequently occurred at the top one in seven cancer types (including BC, GC, GBM, MB, MM, NB and OC), even though only two or three known-disease genes existed in NB, GBM and MB gene lists. This evidence concerns the gene CDH1 and breast cancer.