Similarly, the KMT2A-AFF1 fusion identified in UPN14 at t-ALL diagnosis, as expected, was undetectable in the primary APL diagnostic sample, and was detected at low levels by Q-RT-PCR 13 months after achievement of complete remission of APL, treated according to the AIDA protocol (Figure 1C, 17). Here, AFF1 is linked to acute promyelocytic leukemia.