CDH2 and gastric cancer: We examined adherent and spheroid gastric cancer cells, and the results showed that the EMT of cells cultured in spheroids method did not change significantly compared with adherent cells (Supplementary Figure S1).Therefore, we investigated a possible link between the generation of EMT-like CSCs and hypoxia by measuring E-cadherin, Vimentin and N-cadherin expression to evaluate EMT progression.