The p53-deficient lung cancer cells (H1299, HOP92, and KP7B), as well as the p53-deficient prostate cancer cells (PC-3), and the wild-type p53-expressing lung cancer cells (H460) were sensitive to apoptosis when co-cultured with Par-4+/+ MEFs and treated with CQ (Figure 2A). Here, TP53 is linked to lung cancer.