High expression of ARID2, JMJD1C, MBNL1, MEF2C, or RUNX2 alone is associated with at least one indicator of poor prognosis in ALL patients (Table S4), and CPEB2, MBNL1, RUNX2, and ZEB2 are all specifically overexpressed in MLL-FP leukemias (Figures 4H and S5A; Table S5). The gene discussed is RUNX2; the disease is leukemia.