KMT2A and leukemia: Importantly, wild-type MLL spreading is not observed in non-MLLr leukemia cell lines (RCH-ACV or CCRF-CEM), at wild-type MLL binding sites in SEM cells (Figures 4C and 4D), or for wild-type MLL(C) in MV4;11 cells (Zhu et al., 2016) (Figure S4C).