However, there is evidence that clinical and immunological factors (recent infection, vaginal infections, viral load of pregnant women and low CD4+ count), obstetric issues (vaginal delivery and premature birth), factors relating to the newborn (breastfeeding and antiretroviral prophylaxis for newborns), absence of antiretroviral therapy during pregnancy and behavioral factors (young maternal age and use of drugs by pregnant women) influence vertical transmission.14 The gene discussed is CD4; the disease is infective vaginitis.