Our results showed adecrease of nitrite levels in SAS group may be due to endothelium dysfunction.Moreover, we did not observe an increase in nitrite levels in patients with TAO andthis can be explained at least in part because of the higher levels of ROS whichcould increase the nitrite levels by inducible NOS activation, an enzyme whichproduces high quantities of NO, resulting in more oxidativestress[11,21]. Here, NOS2 is linked to SATB2 associated disorder.