MAS1 and chronic kidney disease: (24) demonstrated that treatment withAng(1-7) significantly decreased plasma levels of AngII and hypothesized that Ang(1-7)could promote the increased degradation of Ang II and thereby confer protection in CKD.It was proposed that the activation of the counter-regulatory RAS axis,ACE2-Ang(1-7)-Mas, could oppose the effects of the ACE-Ang II-AT1 axis and prevent orreverse organ damage.