ACE2 and obstructive sleep apnea syndrome: Other studies demonstrated that both apoptosis and oxidativestress, two processes that are associated with I/R and are influenced by Ang II, wereexacerbated by the loss of the Ace2 gene (31,32) and that repetitiveepisodes of hypoxia/reoxygenation that are associated with the transient cessation ofbreathing during sleep in OSA resemble I/R injury (33).