INS and diabetes mellitus: Studies that compared metformin users to women with diabetes treated with sulphonylurea or insulin (non-metformin) showed no difference in ER status [20,44], but sulphonylurea or insulin users presented more PR-negative tumors (63.0% versus 26.7%, p = 0.041) [44] and more HER-2 positive (29.5% versus 21%, p = 0.002) [20] than in the metformin-treated subgroup.