TNF and heart failure: Besides RAS-/NEP-inhibition, also TNF-alpha blockade by etanercept [32], cardiac resynchronization by biventricular pacing [41], treatment with resveratrol in doxorubicin-induced heart failure [42], or application of trimetazidine [43] were likewise followed by ETC adaptations, thereby indicating a therapeutic involvement of the ATP-generating apparatus in these instances.