It is noteworthy that very similar findings were recently reported for the RAS-/NEP-inhibitor LCZ696 in the PARAMOUNT trial [30], which compared LCZ696 to valsartan in patients with HFPEF (i.e., heart failure with preserved ejection fraction): in this study parameters of left atrial remodeling were significantly improved after 36 weeks, whereas indicators for left ventricular remodeling remained unchanged. The gene discussed is MME; the disease is heart failure.