In the IHC assay, we also found that the levels of FUBP1 protein expression were significantly upregulated in ccRCC tissues as compared with the matched normal renal tissues from the same patient, FUBP1 was almost exclusively localized in the nucleus of ccRCC cells (Fig 1D and 1E). Here, FUBP1 is linked to nonpapillary renal cell carcinoma.