In accordance with previous studies and our hypothesis, after stratifying patients into 2 groups according to the optimal cut-off value of AGR, the subgroup with lower AGR (< 0.6) were associated with the following clinicopathological features: (1) higher Child-Pugh grade and higher ALBI score, which reflected impaired liver function; (2) raised ALT, ALP, which were also commonly as indicators of inflammation; (3) elevated tumor markers (CEA, CA19-9), larger tumor size, multiple tumors, the presence of lymph node metastasis and advanced clinical stage. Here, GPT is linked to metastatic malignant neoplasm in the lymph nodes.