The high-risk AGR group was presented with higher Child-Pugh grade (P = 0.01), higher albumin-bilirubin (ALBI) grade (P = 0.001) [34, 35], elevated alanine transaminase (ALT; P < 0.001), alkaline phosphatase (ALP; P < 0.001), carbohydrate antigen 19-9 (CA19-9; P = 0.001) and carcinoembryonic antigen (CEA; P = 0.008) levels, larger tumor size (P = 0.001), multiple tumors (P = 0.03), the presence of lymph node metastasis (P = 0.001) and advanced TNM stage (P < 0.001). The gene discussed is ALB; the disease is metastatic malignant neoplasm in the lymph nodes.