Moreover, many studies have documented specific patterns of increased levels of cytokines in different phases of BD: namely, the pro-inflammatory cytokines increased during mania seem to be IL-2, IL-6, IL-8 and INF-γ, whereas only IL-6 is increased during depressive episodes, with an imbalance between IL-6 levels and those of the anti-inflammatory cytokine IL-10 [105]. Here, IL6 is linked to Behcet disease.