Interestingly, H3K9me3 is up-regulated in adeonomas and is a significantly increased in adenocarcinoma, suggesting H3K9me3 level is involved in the progression from adenoma to adenocarcinoma [83] Conversely, a study of H3K27me3 and its associated polycomb proteins EZH2, BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) and SUZ12 revealed high expression of all four correlated with improved overall survival and recurrence-free survival [50]. The gene discussed is BMI1; the disease is adenoma.