CTNNB1 and obesity due to melanocortin 4 receptor deficiency: According to another study, obesity and physical inactivity are associated with a higher risk of CTNNB1-negative CRC, but not of CTNNB1-positive CRC, suggesting that the energy balance and the metabolic state exert effects on a specific carcinogenesis pathway that is less likely to be dependent on WNT/CTNNB1 activation [239].