The downregulation of RhoA, an upstream activator of ROK48 and the direct inhibition of ROK by Incarvine C and Y27632 decreased the phosphorylation of MYPT1 at Thr850 in lung cancer and HCC49, respectively, and the ROK-phosphorylated MYPT1 was localized not only in the cytoplasm but in the nucleus as well50. This evidence concerns the gene RHOA and lung carcinoma.