Our results imply that the decreased activity of MP bears an obvious relation to the increased activity of PRMT5 and the increased gene repression mark on histones in almost every investigated cancer types particularly in bladder and colon carcinoma, MCF7 breast cancer, THP1 monocytic leukemia, kidney adenocarcinoma and in hepatocellular carcinoma. The gene discussed is PRMT5; the disease is renal cell adenocarcinoma.